TEAD / Hippo Pathway — Targeted Therapies, Trials & Pipeline
TEAD transcription factors (TEAD1–4) are the nuclear effectors of the Hippo tumor-suppressor pathway; when upstream signaling is lost (via NF2, LATS1/2 inactivation), oncoproteins YAP and TAZ drive TEAD-dependent proliferative and survival programs — the target of TEAD inhibitors in mesothelioma.