ACTS-GC — Adjuvant S-1 Chemotherapy After D2 Gastrectomy for Stage II/III Gastric Cancer

Phase 3 · 2007 · Gastric Cancer

Design

Randomized 1 year of adjuvant oral S-1 vs surgery alone after D2 gastrectomy.

Population

Stage II/III gastric cancer resected with D2 lymphadenectomy in Japan.

Primary Endpoint

overall survival (OS)

Key Result

Adjuvant S-1 improved 5-year OS from 61% to 72% (HR 0.67) after curative D2 resection.

Guideline Impact

Standard adjuvant option after D2 gastrectomy in Asian gastric cancer guidelines