CALGB 9343 — Lumpectomy Plus Tamoxifen With or Without Radiation in Older Women With Early Estrogen-Receptor-Positive Breast Cancer

Phase 3 · 2004 · Breast Cancer

Design

Randomized lumpectomy plus tamoxifen with or without adjuvant breast irradiation.

Population

Women aged 70 or older with clinical stage I (T1N0) estrogen-receptor-positive breast cancer.

Primary Endpoint

locoregional recurrence

Key Result

At 10 years, radiation reduced locoregional recurrence (2% vs 10%) but did not improve distant metastasis, breast preservation, or overall survival.

Guideline Impact

NCCN supports omitting radiotherapy in selected women >=70 with T1N0 ER-positive breast cancer