AMAROS — Axillary Radiotherapy Versus Axillary Dissection for Sentinel-Node-Positive Breast Cancer

Phase 3 · 2014 · Breast Cancer

Design

Randomized completion axillary lymph node dissection vs axillary radiotherapy in patients with a positive sentinel node.

Population

T1-2, clinically node-negative breast cancer with a positive sentinel node.

Primary Endpoint

axillary recurrence (non-inferiority)

Key Result

Axillary radiotherapy gave comparable, excellent regional control with significantly less lymphedema than axillary dissection.

Guideline Impact

Basis for axillary radiotherapy as an alternative to ALND in node-positive breast cancer