HD15 — Escalated-Dose BEACOPP Regimens and PET-Guided Radiotherapy for Advanced Hodgkin Lymphoma

Phase 3 · 2012 · Classical Hodgkin Lymphoma

Design

Randomized 8 vs 6 cycles of escalated BEACOPP vs BEACOPP-14, with radiotherapy limited to PET-positive residual masses.

Population

Advanced-stage classical Hodgkin lymphoma.

Primary Endpoint

freedom from treatment failure

Key Result

6 cycles of escalated BEACOPP were more effective and less toxic than 8 cycles; PET-guided radiotherapy safely spared most patients consolidation radiation.

Guideline Impact

Basis for escalated-BEACOPP and PET-guided radiation strategies in advanced Hodgkin lymphoma