GOG-122 — Randomized Phase III Trial of Whole-Abdominal Irradiation Versus Doxorubicin and Cisplatin Chemotherapy in Advanced Endometrial Carcinoma: A Gynecologic Oncology Group Study

Phase 3 · 2006 · Endometrial Cancer

Design

Randomized phase 3 trial comparing whole-abdominal irradiation versus combination doxorubicin plus cisplatin chemotherapy after surgery.

Population

Women with FIGO stage III or IV endometrial carcinoma with no more than 2 cm of postoperative residual disease.

Primary Endpoint

Progression-free survival and overall survival

Key Result

Chemotherapy significantly improved outcomes versus whole-abdominal radiation, with a 50% 5-year PFS vs 38% (adjusted HR 0.71) and 55% vs 42% 5-year OS (adjusted HR 0.68).

Guideline Impact

Shifted advanced endometrial cancer standard from radiation to chemotherapy