MSLT-II — Completion Lymph-Node Dissection Versus Observation for Sentinel-Node Metastasis in Melanoma

Phase 3 · 2017 · Melanoma

Design

Randomized immediate completion lymph-node dissection vs nodal observation with ultrasound in sentinel-node-positive melanoma.

Population

Cutaneous melanoma with a positive sentinel lymph node.

Primary Endpoint

melanoma-specific survival

Key Result

Completion dissection did not improve melanoma-specific survival but increased lymphedema; it improved regional disease control and staging only.

Guideline Impact

Basis for nodal observation over completion dissection in melanoma guidelines