NSABP B-06 — Total Mastectomy Versus Lumpectomy With or Without Radiation for Early Invasive Breast Cancer

Phase 3 · 1985 · Breast Cancer

Design

Randomized total mastectomy vs lumpectomy alone vs lumpectomy plus breast irradiation.

Population

Stage I/II invasive breast cancer with tumors up to 4 cm (node-positive or -negative).

Primary Endpoint

disease-free, distant-disease-free, and overall survival

Key Result

At 20 years, no difference in overall survival among the three groups; radiation after lumpectomy cut ipsilateral recurrence from 39% to 14%.

Guideline Impact

Foundational evidence for breast-conserving therapy in NCCN and all major guidelines