RTOG 9402 — Radiation With or Without PCV Chemotherapy for Anaplastic Oligodendroglial Tumors

Phase 3 · 2013 · Glioma

Design

Randomized dose-intense PCV chemotherapy followed by radiation vs radiation alone.

Population

Anaplastic oligodendroglioma and anaplastic oligoastrocytoma.

Primary Endpoint

overall survival (OS)

Key Result

In 1p/19q-codeleted tumors, adding PCV nearly doubled median survival (14.7 vs 7.3 years); no benefit in non-codeleted tumors.

Guideline Impact

Basis for 1p/19q-directed chemoradiation in anaplastic oligodendroglioma