RTOG 9802 — Radiation Therapy With or Without PCV Chemotherapy for High-Risk Low-Grade Glioma

Phase 3 · 2016 · Glioma

Design

Randomized radiation alone vs radiation followed by 6 cycles of PCV (procarbazine, lomustine, vincristine).

Population

High-risk (age =40) WHO grade 2 low-grade glioma.

Primary Endpoint

overall survival (OS)

Key Result

Adding PCV extended median OS from 7.8 to 13.3 years (HR 0.59), a striking near-doubling of survival.

Guideline Impact

NCCN standard-of-care basis for chemoradiation in high-risk low-grade glioma