A021703 / SOLARIS — Adding high-dose vitamin D3 to chemotherapy and bevacizumab in metastatic colorectal cancer

Phase 3 · Colorectal Cancer

Population

Previously untreated metastatic colorectal cancer.

Primary Endpoint

Progression-free survival

Rationale

Observational data link higher vitamin D levels to better colorectal cancer outcomes. SOLARIS tests whether adding high-dose vitamin D3 to standard first-line chemotherapy and bevacizumab improves survival in a randomized trial.

What It Could Change

Would show whether an inexpensive supplement meaningfully adds to first-line colorectal cancer treatment.