BWEL / A011401 — Telephone-based weight-loss intervention after breast cancer

Phase 3 · Breast Cancer

Population

Overweight or obese women with stage II–III HER2-negative breast cancer.

Primary Endpoint

Invasive disease-free survival

Rationale

Obesity is linked to worse breast cancer outcomes, but whether intentional weight loss after diagnosis improves survival has never been proven in a randomized trial. BWEL tests a structured telephone-based weight-loss program to answer that question directly.

What It Could Change

Would show whether an inexpensive lifestyle intervention can improve cancer outcomes — a rare non-drug question at this scale.