ECOG-ACRIN EA1151 / TMIST — Tomosynthesis Mammographic Imaging Screening Trial (TMIST)

Screening (randomized) · Breast Cancer

Population

Women eligible for routine screening mammography.

Primary Endpoint

Cumulative incidence of advanced breast cancers

Rationale

Tomosynthesis increases cancer detection and reduces recall rates, but it is unknown whether it reduces clinically significant advanced cancers versus standard 2D mammography.

What It Could Change

A positive result would justify tomosynthesis as the preferred primary breast cancer screening modality.