AL102 — Investigational Agent
Other · Phase 2/3 · Ayala Pharmaceuticals / Immunome
Mechanism of Action
Oral gamma-secretase inhibitor that blocks proteolytic activation of the Notch receptor, downregulating Notch pathway signaling that drives proliferation in desmoid tumors (many of which harbor CTNNB1/Notch pathway dependence).
Investigational Indications
- Progressing desmoid tumors
- Aggressive fibromatosis