Anetumab ravtansine — Investigational Agent
Antibody-Drug Conjugate · Phase 1/2 · Bayer
Mechanism of Action
Anetumab ravtansine is a mesothelin-directed antibody-drug conjugate linked to the maytansinoid DM4, which is internalized by mesothelin-expressing cells and disrupts microtubules to trigger cell death.
Investigational Indications
- Mesothelin-expressing ovarian cancer
- Mesothelioma
- Mesothelin-expressing pancreatic and other solid tumors