CBL0137 — Investigational Agent
Other · Phase 1 · Children's Oncology Group / Incuron
Mechanism of Action
Curaxin that targets the FACT (facilitates chromatin transcription) complex, simultaneously suppressing NF-kB and HSF1 while activating p53 ('c-trapping'), producing anti-proliferative effects across chromatin-dependent pediatric malignancies.
Investigational Indications
- Relapsed/refractory pediatric solid tumors
- Pediatric CNS tumors
- Neuroblastoma