CLN-619 — Investigational Agent
Monoclonal Antibody · Phase 1 · Cullinan Oncology
Mechanism of Action
A monoclonal antibody that blocks shedding of MICA and MICB stress ligands, stabilizing their surface expression so NKG2D-bearing NK and T cells can recognize and kill tumor cells while preventing immunosuppressive soluble MICA/B.
Investigational Indications
- Advanced solid tumors
- Non-small cell lung cancer
- Gynecologic malignancies